GOP convention helps Univision win viewers 18-49

NEW YORK ?

Univision can thank the Republicans for a milestone week in the television ratings.

Nielsen said the Spanish-language network topped prime-time ratings last week among viewers ages 18 to 49. It was only the fourth time in Univision's history that it achieved that feat and the first time it happened twice in the same year. It also happened in early July.

ABC, CBS and NBC each televised three hours of the Republican National Convention last week, and that was a turnoff to the young viewers prized by advertisers. Sixteen of Univision's one-hour telenovela episodes did better in the ratings among that demographic than any hour of convention coverage.

During the otherwise quiet week before Labor Day, NBC's "America's Got Talent" was the most-watched program.

CBS averaged 4.9 million viewers for the week in prime time (3.3 rating, 6 share). NBC was second with 3.9 million (2.6, 5), ABC had 3.9 million (2.6, 4), Fox had 3.4 million (2.1, 4), ION Television had 1.2 million (0.8, 1) and the CW had 740,000 (0.5, 1).

Among the Spanish language networks, Univision led with a 3.4 million average (1.8 rating, 3 share). Telemundo had 1.2 million (0.7, 1), TeleFutura had 550,000 (0.3, 1), Estrella had 160,000 and Azteca had 90,000 (both 0.1, 0).

NBC's "Nightly News" topped the evening newscasts with an average of 7.9 million viewers (5.4, 11). ABC's "World News" was second with 7.2 million (4.9, 10) and the "CBS Evening News" had 6 million viewers (4.3, 8).

A ratings point represents 1,147,000 households, or 1 percent of the nation's estimated 114.7 million TV homes. The share is the percentage of in-use televisions tuned to a given show.

For the week of Aug. 27-Sept. 2, the top 10 shows, their networks and viewerships: "America's Got Talent" (Tuesday), NBC, 9.89 million; "NCIS," CBS, 8.38 million; "America's Got Talent" (Wednesday), NBC, 8.34 million; College Football: Michigan vs. Alabama, ABC, 7.92 million; "NCIS: Los Angeles," CBS, 7.2 million; "60 Minutes," CBS, 6.96 million; "Hell's Kitchen" (Monday), Fox, 6.87 million; "2 Broke Girls" (Monday, 9 p.m.), CBS, 6.63 million; "Master Chef" (Tuesday), Fox, 6.59 million; "The Big Bang Theory" (Monday, 8:30 p.m.), CBS, 6.51 million.

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ABC is owned by The Walt Disney Co. CBS is owned by CBS Corp. CW is a joint venture of Warner Bros. Entertainment and CBS Corp. Fox and My Network TV are units of News Corp. NBC and Telemundo are owned by Comcast Corp. ION Television is owned by ION Media Networks. TeleFutura is a division of Univision. Azteca America is a wholly owned subsidiary of TV Azteca S.A. de C.V.

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Online:

http://www.nielsen.com

Source: http://feeds.seattletimes.com/click.phdo?i=00acd1801dd9790ae37a5523164b9184

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Galileo didn't invent thermometer that bears his name

ScienceDaily (Sep. 5, 2012) ? The great Italian scientist Galileo may have been the first person to use a telescope to observe the heavens, helping spark the scientific revolution of the 16th century, but Galileo definitely did not invent the famous thermometer and captivating curiosity that bears his name.

That's the message of an article in ACS' Journal of Chemical Education.

Peter Loyson explains that a number of companies sell so-called "Galilean thermometers," sealed tubes of liquid in which glass spheres float and sink with changes in ambient temperature. Modern versions have morphed into elegant curiosity pieces with multi-colored spheres and gold-plated temperature tags. The instruments rely on a liquid, like water or alcohol, whose density increases as temperature falls. The glass spheres each are made to a precise density that matches that of the suspension liquid at a specific temperature. When a sphere floats midway up the tube, it represents the temperature of the room.

Although Galileo may have originated the idea in a 1638 book, the Accademia del Cimento, an early scientific society founded in Florence in 1657 by Galileo's students, actually deserves the credit, Loyson says. The Accademia del Cimento -- "the Academy of Experiment" -- developed other instruments, as well. Loyson suggests "Florentine thermometer" as a more appropriate name for these colorful marvels.

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The above story is reprinted from materials provided by American Chemical Society, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Peter Loyson. Galilean Thermometer Not So Galilean. Journal of Chemical Education, 2012; 120727090015004 DOI: 10.1021/ed200793g

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/UazBMqDuCtM/120905111140.htm

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Millions of DNA switches that power human genome's operating system are discovered

ScienceDaily (Sep. 5, 2012) ? The locations of millions of DNA 'switches' that dictate how, when, and where in the body different genes turn on and off have been identified by a research team led by the University of Washington in Seattle. Genes make up only 2 percent of the human genome and were easy to spot, but the on/off switches controlling those genes were encrypted within the remaining 98 percent of the genome.

Without these switches, called regulatory DNA, genes are inert. Researchers around the world have been focused on identifying regulatory DNA to understand how the genome works. Using a new technology developed with funding from the National Human Genome Research Institute's ENCODE (ENCyclopedia Of DNA Elements) project, UW researchers created the first detailed maps of where regulatory DNA is located within hundreds of different kinds of living cells. They also compiled a dictionary of the instructions written within regulatory DNA -- the genome's programming language.

The findings are reported in two papers appearing in the Sept. 5 online issue of Nature.

"These breakthrough studies provide the first extensive maps of the DNA switches that control human genes," said Dr. John A. Stamatoyannopoulos, associate professor of genome sciences and medicine at the University of Washington, and senior author on both papers. "This information is vital to understanding how the body makes different kinds of cells, and how normal gene circuitry gets rewired in disease. We are now able to read the living human genome at an unprecedented level of detail, and to begin to make sense of the complex instruction set that ultimately influences a wide range of human biology."

Here are the key results:

1) The first detailed maps of regulatory DNA switches that make up the genome's 'operating system'.

The instructions within regulatory DNA are inscribed in small DNA 'words' that function as the docking sites for special proteins involved in gene control. In many cases, these switches are located far away from the genes that they control. To map the regulatory DNA regions, the researchers harnessed a special molecular probe -- an enzyme called DNaseI -- that snips the genome's DNA backbone. Under the right conditions, these snips occur precisely where proteins are docked at regulatory DNA. By treating cells with DNase I and analyzing the patterns of snipped DNA sequences using massively parallel sequencing technology and powerful computers, the researchers were able to create comprehensive maps of all the regulatory DNA in hundreds of different cell and tissue types. They found that of the 2.89 million regulatory DNA regions they mapped, only a small fraction -- around 200,000 -- were active in any given cell type. This fraction is almost totally unique to each type of cell and becomes a sort of molecular bar code of the cell's identity. The researchers also developed a method for linking regulatory DNA to the genes it controls. The results of these analyses show that the regulatory 'program' of most genes is made up of more than a dozen switches. Together, these findings greatly expand the understanding of how genes are controlled and how that control may differ between normal and diseased cells.

2) The first extensive map of regulatory protein docking sites on the human genome reveals the dictionary of DNA words comprise the genome's programming language.

The instructions for turning genes on and off are written in DNA switches called regulatory DNA. These switches are scattered throughout the non-gene regions of the human genome. Having mapped the locations of the regulatory DNA switches, UW researchers wanted to know what made them tick. These regions contain small chains of DNA 'words' that make up docking sites for special regulatory proteins involved in gene control. The human genome contains hundreds of genes that make such proteins.

However, current technologies only allow such proteins to be studied one at a time. They also lack the accuracy to resolve the DNA letters to which the proteins dock. As a result, most of the actual DNA words recognized by regulatory proteins in living cells were unknown. To find them, the researchers employed a simple, powerful trick that enabled them to study all the proteins at once.

Instead of trying to see proteins directly, they looked for their shadows or 'footprints' on the DNA. To accomplish this, they again turned to the DNaseI enzyme that snips the DNA backbone within regulatory DNA. Prior work had shown that DNaseI likes to snip DNA next to regulatory protein docking sites, but not within the docking site itself. By using next-generation DNA sequencing technology, the researchers analyzed hundreds of millions of DNA backbone breaks made when cells were treated with DNaseI. They then used a powerful computer to resolve millions of protein footprints. In total, they identified 8.4 million such footprints along the genome, some of which were detected in many cell types. Next, they compiled all of the short DNA sequences to which the proteins were docked. They analyzed them using a software algorithm that required hundreds of microprocessors working simultaneously. This revealed that more than 90 percent of the protein docking sites were actually slight variants of 683 different DNA words -- essentially a dictionary of the genome's programming language.

"These findings significantly advance the understanding of how the instructions for controlling genes are written and organized throughout the genome, and how combinations of different instruction sets function together to control genes, often at great distance along the genome," Stamatoyannopoulos said. "The broad spectrum of cell and tissue types included in these analyses provide an incredibly rich resource that can be mined immediately by researchers around the world to illuminate how the genes they are studying are controlled."

The scientists determined that genes are connected in a complex web. In this web, regulatory DNA regions typically control one or at most a few genes, but genes receive inputs from large numbers of regulatory regions. The researchers also found evidence for a combinatorial code that helps match regulatory DNA with the right genes. Another key finding was that the regulatory DNA controlling genes involved in cancer and other types of 'immortal' cells that can keep on growing indefinitely appears to acquire mutations at a different rate than other kinds of regulatory DNA. This result points to a previously unknown link between genome function and patterns of DNA variation in individual human genomes. The finding may have implications for understanding susceptibility to cancer.

The findings reported in these papers are expanded upon in two related papers to be published simultaneously in the journals Science and Cell. In the Science paper, UW researchers further expanded the regulatory DNA maps, and compared them with genetic maps of human disease. Their studies revealed that most DNA variants associated with specific human diseases or clinical traits are located in regulatory DNA rather than in gene sequences. In the Cell paper, the researchers describe using the detailed information on regulatory protein docking sites to create a comprehensive map of how those proteins are wired.

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Story Source:

The above story is reprinted from materials provided by University of Washington. The original article was written by Stephanie Seiler And Leila Gray.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal References:

  1. Shane Neph, Jeff Vierstra, Andrew B. Stergachis, Alex P. Reynolds, Eric Haugen, Benjamin Vernot, Robert E. Thurman, Sam John, Richard Sandstrom, Audra K. Johnson, Matthew T. Maurano, Richard Humbert, Eric Rynes, Hao Wang, Shinny Vong, Kristen Lee, Daniel Bates, Morgan Diegel, Vaughn Roach, Douglas Dunn, Jun Neri, Anthony Schafer, R. Scott Hansen, Tanya Kutyavin, Erika Giste, Molly Weaver, Theresa Canfield, Peter Sabo, Miaohua Zhang, Gayathri Balasundaram, Rachel Byron, Michael J. MacCoss, Joshua M. Akey, M. A. Bender, Mark Groudine, Rajinder Kaul, John A. Stamatoyannopoulos. An expansive human regulatory lexicon encoded in transcription factor footprints. Nature, 2012; 489 (7414): 83 DOI: 10.1038/nature11212
  2. Robert E. Thurman, Eric Rynes, Richard Humbert, Jeff Vierstra, Matthew T. Maurano, Eric Haugen, Nathan C. Sheffield, Andrew B. Stergachis, Hao Wang, Benjamin Vernot, Kavita Garg, Sam John, Richard Sandstrom, Daniel Bates, Lisa Boatman, Theresa K. Canfield, Morgan Diegel, Douglas Dunn, Abigail K. Ebersol, Tristan Frum, Erika Giste, Audra K. Johnson, Ericka M. Johnson, Tanya Kutyavin, Bryan Lajoie, Bum-Kyu Lee, Kristen Lee, Darin London, Dimitra Lotakis, Shane Neph, Fidencio Neri, Eric D. Nguyen, Hongzhu Qu, Alex P. Reynolds, Vaughn Roach, Alexias Safi, Minerva E. Sanchez, Amartya Sanyal, Anthony Shafer, Jeremy M. Simon, Lingyun Song, Shinny Vong, Molly Weaver, Yongqi Yan, Zhancheng Zhang, Zhuzhu Zhang, Boris Lenhard, Muneesh Tewari, Michael O. Dorschner, R. Scott Hansen, Patrick A. Navas, George Stamatoyannopoulos, Vishwanath R. Iyer, Jason D. Lieb, Shamil R. Sunyaev, Joshua M. Akey, Peter J. Sabo, Rajinder Kaul, Terrence S. Furey, Job Dekker, Gregory E. Crawford, John A. Stamatoyannopoulos. The accessible chromatin landscape of the human genome. Nature, 2012; 489 (7414): 75 DOI: 10.1038/nature11232

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/vkalkuhqlIQ/120905135326.htm

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Bosnian Serbs Shrug Off Socialist International Snub :: Balkan Insight

Elvira M. Jukic

The Executive Secretary of the Alliance of Independent Social Democrats, Rajko Vasic, led by the Bosnian Serb leader Milorad Dodik, said the party will not go into mourning following its exclusion from the Socialist International several days ago.

Vasic said the party will not "veil itself in black", as the decision merely marked the continuation of a policy of discrimination against Serbs that had gone on for the past two decades.

?We will not wear black because of that,? Vasic said. ?We will go on with our political program of responding to all the needs of our citizens.?

He said that the SNSD had nurtured many other contacts in the world beyond the Socialist International which, he said, had evidently sided with Bosnia's mainly Bosniak [Muslim] Social Democratic Party, SDP.

The SDP, meanwhile, said that excluding Dodik's party reflected the fact that the SNSD had abandoned social democracy for ethnic nationalism and separatism.

?The denial of the state of Bosnia and Herzegovina and its attempts to twist historical facts from the recent past about the [1995] Srebrenica genocide only hastened the process of the exclusion of Dodik's SNSD from the Socialist International,? the SDP said.

It added that all the other member parties supported the decision ?which illustrates the political and ideological turn of Dodik's party, causing... it to be excluded from the world family of social democrats.?

Source: http://www.balkaninsight.com/en/article/socialist-international-excludes-milorad-dodik-s-party

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iOS 6 preview: Passbook

iOS 6 preview: Passbook

Passbook is a brand new, built-in app for iOS 6 designed to serve as a one-stop repository for all the tickets, coupons, gift cards, and other vouchers provided by third-party App Store apps. That means all the stuff in your Apple Store app, Starbucks app, Delta app, Fandango app, and more is easily accessible via a single Home screen icon, and what's more -- Passbook knows what time it is and where you are, so it can put whatever card you need right on your Lock screen, right when you need it.

Here's what Apple has to say about Passbook:

Your boarding passes, movie tickets, retail coupons, loyalty cards, and more are now all in one place. With Passbook, you can scan your iPhone or iPod touch to check in for a flight, get into a movie, and redeem a coupon. You can also see when your coupons expire, where your concert seats are, and the balance left on that all-important coffee bar card. Wake your iPhone or iPod touch, and passes appear on your Lock screen at the appropriate time and place ? like when you reach the airport or walk into the store to redeem your gift card or coupon. And if your gate changes after you?ve checked in for your flight, Passbook will even alert you to make sure you?re not relaxing in the wrong terminal.

And here's what they've shown off of it so far:

  • According to Apple, "Passbook is the simplest way to get all your passes in one place." That's in contrast to the current, iOS 5 situation where tickets, gift cards, confirmations, coupons, are scattered across a variety of App Store apps.

  • When you get to the airline gate, the Starbucks line, or the movie theater, however, instead of having to find the appropriate app, launch it, and then find the appropriate pass in the app, Passbook collects them all together for you in one place.

  • Simply tap the pass you want to access, and it comes up full screen.

  • If you have more than one pass for the same thing -- 2 tickets for Amtrack, 3 coupons for Target, etc. -- you can swipe between them in full-screen mode.

  • Apple, of course, has designed them all beautifully...

  • ...And has created templates to help developers make beautiful passes of their own.

  • If the pass is a gift card, it can show up-to-date balance information right on the front.

  • If the pass is a ticket, and something like the gate changes, that will also be displayed right on the front.

  • To see additional information about a pass, tap the info button at the bottom right and it'll flip over, just like the Weather or Stocks apps. On the back, you can toggle Lock screen notifications on or off, and see additional information like confirmation numbers, locations, and other details about the specific pass.

  • And if you don't want the pass anymore, you can tap the trashcan button, confirm the deletion, and Apple will shred it for you in digital form.

  • Conveniently, Passbook can also present Lock screen notifications based on time and location. So you when you arrive at the right time or the right place, your passes pop up.

  • If something changes, like the gate information, you'll get a notification as well. And multiple notifications stack up, just as you'd expect.

Passbook is interesting in that a) instead of making a repository for something traditional, like documents, Apple is doing it for something still on the horizon, digital vouchers; and b) unlike Google and Microsoft, it's not yet a real mobile wallet with built-in payments yet.

That makes Passbook stuck in both the past and the future. It has QR and bar codes, not NFC or other wireless transaction processing. It hooks into existing apps, not Apple's massive iTunes cash register. It feels like a first step, a testing of the waters. The only question is how long it takes mainstream users to decide those waters and fine, and want to dive in, and for Apple to get the partnerships in place to take that next step.

For now, however, if you have passes in apps, Passbook makes it easier than ever to swipe, scan, and go.

iOS 6 is scheduled for release this fall, perhaps as soon as September 19. For more on iOS 6 check out:

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/fRe6TkCx1pk/story01.htm

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Group health associates cincinnati - HEALTH, BEAUTY & FITNESS

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Mobile Tech Gives Malware Makers Much Bigger Playground for Mischief

Twitter-controlled mobile botnets and mobile ransomware are a few examples of what's in store for Internet users, according to the second-quarter McAfee Threats Report. In general, mobile tech has emerged as a major vector for hack attacks, with many that might once have been aimed at PCs now focused on other devices.

Source: http://ectnews.com.feedsportal.com/c/34520/f/632000/s/23120551/l/0L0Stechnewsworld0N0Crsstory0C760A730Bhtml/story01.htm

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